BindingDB PrimarySearch

BDBM17664 (2S)-2-amino-3-(phosphonooxy)propanoic acid::CHEMBL284377::L-SOP::L-serine O-phosphate

SMILES: N[C@@H](COP(O)(O)=O)C(O)=O

InChI Key: InChIKey=BZQFBWGGLXLEPQ-REOHCLBHSA-N

Data: 5 KI 1 IC50 5 EC50

PDB links: 1593 PDB IDs match this monomer. 15 PDB IDs contain this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 17664
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 8 (mGlu8) (Rattus norvegicus (Rat))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Toronto Curated by PDSP K_i Database									Neuropharmacology 40: 170-7 (2001) Article DOI: 10.1016/s0028-3908(00)00128-3 BindingDB Entry DOI: 10.7270/Q27P8WZ1
University of Toronto Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									Annu Rev Pharmacol Toxicol 37: 205-37 (1997) Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
UPR Centre Curated by PDSP K_i Database									Mol Pharmacol 50: 923-30 (1996) BindingDB Entry DOI: 10.7270/Q2M61HS5
UPR Centre Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									Annu Rev Pharmacol Toxicol 37: 205-37 (1997) Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GRM7 (Homo sapiens (Human))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									Annu Rev Pharmacol Toxicol 37: 205-37 (1997) Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7) (Rattus norvegicus (Rat))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR7 in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
CNS Research Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR4a in human				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
CNS Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 6 (mGlu6) (Rattus norvegicus (Rat))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR6 in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
CNS Research Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Università di Perugia Curated by ChEMBL					Assay Description Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay				Bioorg Med Chem Lett 10: 1447-50 (2000) BindingDB Entry DOI: 10.7270/Q2VT1R95
Università di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate Carboxypeptidase II (GCPII) (Homo sapiens (Human))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.23E+5	n/a	n/a	n/a	n/a	7.4	37
NCI-FCRDC					Assay Description The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...				J Med Chem 50: 3267-73 (2007) Article DOI: 10.1021/jm070133w BindingDB Entry DOI: 10.7270/Q29C6VPS
NCI-FCRDC					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM17664 ((2S)-2-amino-3-(phosphonooxy)propanoic acid \| CHEM...) Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR4a in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
CNS Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)