BDBM17759 (2S)-2-(phosphonomethyl)pentanedioic acid::(S)-2-PMPA::pentanedioic acid analogue, (S)-1
SMILES: OC(=O)CC[C@H](CP(O)(O)=O)C(O)=O
InChI Key: InChIKey=ISEYJGQFXSTPMQ-SCSAIBSYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM17759 ((2S)-2-(phosphonomethyl)pentanedioic acid | (S)-2-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Curated by ChEMBL | Assay Description Binding affinity to NAALADase | J Med Chem 55: 9510-20 (2012) Article DOI: 10.1021/jm300710j BindingDB Entry DOI: 10.7270/Q28053R3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate Carboxypeptidase II (GCPII) (Homo sapiens (Human)) | BDBM17759 ((2S)-2-(phosphonomethyl)pentanedioic acid | (S)-2-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Guilford | Assay Description GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ... | J Med Chem 48: 2319-24 (2005) Article DOI: 10.1021/jm049258g BindingDB Entry DOI: 10.7270/Q2D50K77 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |