BDBM179706 US9127001, 8m::US9598410, Compound 8m

SMILES: Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CCOC2)-c2cccc(c2)C#N)c(F)c1

InChI Key: InChIKey=HUFBPECTFKXABN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 179706   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium channel protein TASK-1 (Homo sapiens (Human))	BDBM179706 (US9127001, 8m | US9598410, Compound 8m) Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CCOC2)-c2cccc(c2)C#N)c(F)c1 Show InChI InChI=1S/C25H22F2N4O2/c26-20-5-4-18(22(27)11-20)13-31-23-6-8-30(25(32)19-7-9-33-15-19)14-21(23)24(29-31)17-3-1-2-16(10-17)12-28/h1-5,10-11,19H,6-9,13-15H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
SANOFI US Patent					Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...				US Patent US9598410 (2017) BindingDB Entry DOI: 10.7270/Q2377BRM
					More data for this Ligand-Target Pair
Potassium channel protein TASK-1 (Homo sapiens (Human))	BDBM179706 (US9127001, 8m | US9598410, Compound 8m) Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CCOC2)-c2cccc(c2)C#N)c(F)c1 Show InChI InChI=1S/C25H22F2N4O2/c26-20-5-4-18(22(27)11-20)13-31-23-6-8-30(25(32)19-7-9-33-15-19)14-21(23)24(29-31)17-3-1-2-16(10-17)12-28/h1-5,10-11,19H,6-9,13-15H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	25
Sanofi US Patent					Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...				US Patent US9127001 (2015) BindingDB Entry DOI: 10.7270/Q2HM576Z
					More data for this Ligand-Target Pair