null

SMILES: CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NC(CCN)c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=WVKHCAZURZXNHZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180966   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180966 (US9133187, I-119) Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NC(CCN)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H27F3N6O/c1-13(2)27-19-26-11-15-8-10-30(12-18(15)28-19)20(31)29-17(7-9-25)14-3-5-16(6-4-14)21(22,23)24/h3-6,11,13,17H,7-10,12,25H2,1-2H3,(H,29,31)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
					More data for this Ligand-Target Pair