BDBM185553 US9156845, 212

SMILES: C1CN(CCO1)c1ncnc2[nH]cc(-c3cnc4cccnn34)c12

InChI Key: InChIKey=BISAHRSNHGARQL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 185553   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S (Homo sapiens (Human))	BDBM185553 (US9156845, 212) Show SMILES C1CN(CCO1)c1ncnc2[nH]cc(-c3cnc4cccnn34)c12 Show InChI InChI=1S/C16H15N7O/c1-2-13-17-9-12(23(13)21-3-1)11-8-18-15-14(11)16(20-10-19-15)22-4-6-24-7-5-22/h1-3,8-10H,4-7H2,(H,18,19,20)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.3	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...				US Patent US9156845 (2015) BindingDB Entry DOI: 10.7270/Q2DB80MW
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM185553 (US9156845, 212) Show SMILES C1CN(CCO1)c1ncnc2[nH]cc(-c3cnc4cccnn34)c12 Show InChI InChI=1S/C16H15N7O/c1-2-13-17-9-12(23(13)21-3-1)11-8-18-15-14(11)16(20-10-19-15)22-4-6-24-7-5-22/h1-3,8-10H,4-7H2,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.26	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...				US Patent US9156845 (2015) BindingDB Entry DOI: 10.7270/Q2DB80MW
					More data for this Ligand-Target Pair