BDBM185953 US9163008, 42::US9656968, Compound 42
SMILES: C[C@@H](CO)Nc1cc(nc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
InChI Key: InChIKey=ATRLVPLKGMTSHY-LBPRGKRZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM185953 (US9163008, 42 | US9656968, Compound 42) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 24 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma, L.P. US Patent | Assay Description For electrophysiological recordings the external solution was either standard, DMEM supplemented with 10 mM HEPES (pH adjusted to 7.34 with NaOH and ... | US Patent US9163008 (2015) BindingDB Entry DOI: 10.7270/Q2G44P21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM185953 (US9163008, 42 | US9656968, Compound 42) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description Cells: The hNav1.7 expressing HEK-293 cells were plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Mediate... | US Patent US9656968 (2017) BindingDB Entry DOI: 10.7270/Q2F76FMS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM185953 (US9163008, 42 | US9656968, Compound 42) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL... | US Patent US9656968 (2017) BindingDB Entry DOI: 10.7270/Q2F76FMS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM185953 (US9163008, 42 | US9656968, Compound 42) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma, L.P. US Patent | Assay Description In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access... | US Patent US9163008 (2015) BindingDB Entry DOI: 10.7270/Q2G44P21 | |||||||||||
More data for this Ligand-Target Pair |