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SMILES: COc1ccc(C)cc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1

InChI Key: InChIKey=CLXXCEACXDYWSU-WUXMJOGZSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187028   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM187028
PNG
(US9169209, Table 3, Compound 61)
Show SMILES COc1ccc(C)cc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O4S/c1-16-5-11-20(28-2)21(14-16)29(26,27)19-9-7-18(8-10-19)24-22(25)12-6-17-4-3-13-23-15-17/h3-15H,1-2H3,(H,24,25)/b12-6+
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Similars
US Patent
n/an/a 1.80n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...

US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair