BDBM188808 US9169260, 74
SMILES: CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cc1F)C1CC1
InChI Key: InChIKey=AUKFLCXWCUBZOW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human)) | BDBM188808 (US9169260, 74) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal GST-tagged full length human IRAK4 expressed in baculovirus-infected insect Sf9 cells using 5FAM-RKRQGSVRRRVH-CO... | ACS Med Chem Lett 6: 677-82 (2015) Article DOI: 10.1021/acsmedchemlett.5b00106 BindingDB Entry DOI: 10.7270/Q2G73GGK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human)) | BDBM188808 (US9169260, 74) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | 7.2 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos... | US Patent US9169260 (2015) BindingDB Entry DOI: 10.7270/Q26H4G6N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |