BDBM189360 SRI35565

SMILES: FC(F)(F)c1ccc(Nc2ncnc3[nH]ncc23)cc1

InChI Key: InChIKey=SUZRTMGAMLZHFJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189360   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitotic kinesin Eg5 (Eg5) (Homo sapiens (Human))	BDBM189360 (SRI35565) Show SMILES FC(F)(F)c1ccc(Nc2ncnc3[nH]ncc23)cc1 Show InChI InChI=1S/C12H8F3N5/c13-12(14,15)7-1-3-8(4-2-7)19-10-9-5-18-20-11(9)17-6-16-10/h1-6H,(H2,16,17,18,19,20)	PDB GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.89E+4	n/a	n/a	n/a	n/a	7.0	25
Southern Research Institute					Assay Description Compounds were first tested in triplicates at 100 uM; hit compounds were further tested with a 10-point twofold serial dilution to confirm their acti...				Chem Biol Drug Des 88: 178-87 (2016) Article DOI: 10.1111/cbdd.12744 BindingDB Entry DOI: 10.7270/Q2NK3CV8
					More data for this Ligand-Target Pair