null

SMILES: CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCN(CC4)C4CC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1

InChI Key: InChIKey=SDEIFUAFVPHPRQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 189602   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189602 (US10213433, Compound 164 | US11369599, Compound 16...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCN(CC4)C4CC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:61| Show InChI InChI=1S/C48H55ClN8O6S/c1-48(2)17-13-35(42(28-48)33-3-5-36(49)6-4-33)31-54-21-23-56(24-22-54)38-9-11-41(45(26-38)63-39-25-34-14-18-50-46(34)52-30-39)47(58)53-64(61,62)40-10-12-43(44(27-40)57(59)60)51-29-32-15-19-55(20-16-32)37-7-8-37/h3-6,9-12,14,18,25-27,30,32,37,51H,7-8,13,15-17,19-24,28-29,31H2,1-2H3,(H,50,52)(H,53,58)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9174982 (2015) BindingDB Entry DOI: 10.7270/Q2RB73D5
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189602 (US10213433, Compound 164 | US11369599, Compound 16...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCN(CC4)C4CC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:61| Show InChI InChI=1S/C48H55ClN8O6S/c1-48(2)17-13-35(42(28-48)33-3-5-36(49)6-4-33)31-54-21-23-56(24-22-54)38-9-11-41(45(26-38)63-39-25-34-14-18-50-46(34)52-30-39)47(58)53-64(61,62)40-10-12-43(44(27-40)57(59)60)51-29-32-15-19-55(20-16-32)37-7-8-37/h3-6,9-12,14,18,25-27,30,32,37,51H,7-8,13,15-17,19-24,28-29,31H2,1-2H3,(H,50,52)(H,53,58)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21V5J59
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189602 (US10213433, Compound 164 | US11369599, Compound 16...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCN(CC4)C4CC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:61| Show InChI InChI=1S/C48H55ClN8O6S/c1-48(2)17-13-35(42(28-48)33-3-5-36(49)6-4-33)31-54-21-23-56(24-22-54)38-9-11-41(45(26-38)63-39-25-34-14-18-50-46(34)52-30-39)47(58)53-64(61,62)40-10-12-43(44(27-40)57(59)60)51-29-32-15-19-55(20-16-32)37-7-8-37/h3-6,9-12,14,18,25-27,30,32,37,51H,7-8,13,15-17,19-24,28-29,31H2,1-2H3,(H,50,52)(H,53,58)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair