null

SMILES: CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@@H]4CCN(CC#N)C4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1

InChI Key: InChIKey=UAHQOGNEQSDSER-UUWRZZSWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 189692   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189692 (US10213433, Compound 262 | US11369599, Compound 26...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@@H]4CCN(CC#N)C4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:58| Show InChI InChI=1S/C45H48ClN9O6S/c1-45(2)14-11-32(39(26-45)30-3-5-33(46)6-4-30)28-53-19-21-54(22-20-53)35-7-9-38(42(24-35)61-36-23-31-12-16-48-43(31)49-27-36)44(56)51-62(59,60)37-8-10-40(41(25-37)55(57)58)50-34-13-17-52(29-34)18-15-47/h3-10,12,16,23-25,27,34,50H,11,13-14,17-22,26,28-29H2,1-2H3,(H,48,49)(H,51,56)/t34-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9174982 (2015) BindingDB Entry DOI: 10.7270/Q2RB73D5
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189692 (US10213433, Compound 262 | US11369599, Compound 26...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@@H]4CCN(CC#N)C4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:58| Show InChI InChI=1S/C45H48ClN9O6S/c1-45(2)14-11-32(39(26-45)30-3-5-33(46)6-4-30)28-53-19-21-54(22-20-53)35-7-9-38(42(24-35)61-36-23-31-12-16-48-43(31)49-27-36)44(56)51-62(59,60)37-8-10-40(41(25-37)55(57)58)50-34-13-17-52(29-34)18-15-47/h3-10,12,16,23-25,27,34,50H,11,13-14,17-22,26,28-29H2,1-2H3,(H,48,49)(H,51,56)/t34-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition constant (Ki) for binding of representative compounds to Bcl-2 protein, as determined by a TR-FRET (Time-Resolved Fluorescence-Resonan...				Citation and Details BindingDB Entry DOI: 10.7270/Q21V5J59
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189692 (US10213433, Compound 262 | US11369599, Compound 26...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@@H]4CCN(CC#N)C4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:58| Show InChI InChI=1S/C45H48ClN9O6S/c1-45(2)14-11-32(39(26-45)30-3-5-33(46)6-4-30)28-53-19-21-54(22-20-53)35-7-9-38(42(24-35)61-36-23-31-12-16-48-43(31)49-27-36)44(56)51-62(59,60)37-8-10-40(41(25-37)55(57)58)50-34-13-17-52(29-34)18-15-47/h3-10,12,16,23-25,27,34,50H,11,13-14,17-22,26,28-29H2,1-2H3,(H,48,49)(H,51,56)/t34-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair