null

SMILES: CCN(C1CCC(C)(C)CC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C

InChI Key: InChIKey=MGZOOCDTTGHJQB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM190212 (EPZ008991 | US9175331, 48) Show SMILES CCN(C1CCC(C)(C)CC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H36ClN3O2/c1-7-30(20-8-10-26(5,6)11-9-20)23-14-19(27)13-21(18(23)4)24(31)28-15-22-16(2)12-17(3)29-25(22)32/h12-14,20H,7-11,15H2,1-6H3,(H,28,31)(H,29,32)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34.8	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A687V] (Homo sapiens (Human))	BDBM190212 (EPZ008991 | US9175331, 48) Show SMILES CCN(C1CCC(C)(C)CC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H36ClN3O2/c1-7-30(20-8-10-26(5,6)11-9-20)23-14-19(27)13-21(18(23)4)24(31)28-15-22-16(2)12-17(3)29-25(22)32/h12-14,20H,7-11,15H2,1-6H3,(H,28,31)(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19.3	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A677G] (Homo sapiens (Human))	BDBM190212 (EPZ008991 | US9175331, 48) Show SMILES CCN(C1CCC(C)(C)CC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H36ClN3O2/c1-7-30(20-8-10-26(5,6)11-9-20)23-14-19(27)13-21(18(23)4)24(31)28-15-22-16(2)12-17(3)29-25(22)32/h12-14,20H,7-11,15H2,1-6H3,(H,28,31)(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human))	BDBM190212 (EPZ008991 | US9175331, 48) Show SMILES CCN(C1CCC(C)(C)CC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H36ClN3O2/c1-7-30(20-8-10-26(5,6)11-9-20)23-14-19(27)13-21(18(23)4)24(31)28-15-22-16(2)12-17(3)29-25(22)32/h12-14,20H,7-11,15H2,1-6H3,(H,28,31)(H,29,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29.3	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair