BDBM190342 US10227346, Example 93::US10426135, Example 93::US9670201, 93 3-cyano-N-(1,4-dimethyl-3-((2S,4R)-2-methyl-1-((S)-3,3,3-trifluoro-2-methylpropanoyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-methoxybenzamide::US9920054, Example 93
SMILES: COc1ccc(cc1C#N)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN([C@@H](C)C3)C(=O)[C@H](C)C(F)(F)F)c2c1C
InChI Key: InChIKey=FHECTQTXNDHRBR-RYQLBKOJSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM190342 (US10227346, Example 93 | US10426135, Example 93 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 33 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Pfizer Inc. US Patent | Assay Description Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl... | US Patent US9670201 (2017) BindingDB Entry DOI: 10.7270/Q28G8HWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM190342 (US10227346, Example 93 | US10426135, Example 93 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 32.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra... | US Patent US10426135 (2019) BindingDB Entry DOI: 10.7270/Q23N25QB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM190342 (US10227346, Example 93 | US10426135, Example 93 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 32.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Montana State University | J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q2GH9M91 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM190342 (US10227346, Example 93 | US10426135, Example 93 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 32.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Napoli | Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra... | J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2SF2ZGV | |||||||||||
More data for this Ligand-Target Pair |