BDBM196016 US9206199, 121

SMILES: Cc1nc(ncc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc(F)c([N+]#[C-])c1C)-n1cnnn1

InChI Key: InChIKey=STMGYHXHFYPZAR-FXAWDEMLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 196016   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM196016 (US9206199, 121) Show SMILES Cc1nc(ncc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc(F)c([N+]#[C-])c1C)-n1cnnn1 |r| Show InChI InChI=1S/C23H24FN9O2/c1-14-18(4-5-19(24)22(14)25-3)20-11-31-6-7-32(10-17(31)12-35-20)21(34)8-16-9-26-23(28-15(16)2)33-13-27-29-30-33/h4-5,9,13,17,20H,6-8,10-12H2,1-2H3/t17-,20+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9206199 (2015) BindingDB Entry DOI: 10.7270/Q2VH5MND
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM196016 (US9206199, 121) Show SMILES Cc1nc(ncc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc(F)c([N+]#[C-])c1C)-n1cnnn1 |r| Show InChI InChI=1S/C23H24FN9O2/c1-14-18(4-5-19(24)22(14)25-3)20-11-31-6-7-32(10-17(31)12-35-20)21(34)8-16-9-26-23(28-15(16)2)33-13-27-29-30-33/h4-5,9,13,17,20H,6-8,10-12H2,1-2H3/t17-,20+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...				US Patent US9206199 (2015) BindingDB Entry DOI: 10.7270/Q2VH5MND
					More data for this Ligand-Target Pair