null

SMILES: NC(=O)c1nn(-c2ccc(Oc3ccc(c(c3)C#N)C(F)(F)F)cc2)c2ccccc12

InChI Key: InChIKey=KYYGLPGOSWVHNJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 196483   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM196483 (US10202344, Compound 152 | US9212139, 152) Show SMILES NC(=O)c1nn(-c2ccc(Oc3ccc(c(c3)C#N)C(F)(F)F)cc2)c2ccccc12 Show InChI InChI=1S/C22H13F3N4O2/c23-22(24,25)18-10-9-16(11-13(18)12-26)31-15-7-5-14(6-8-15)29-19-4-2-1-3-17(19)20(28-29)21(27)30/h1-11H,(H2,27,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	602	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma L.P. US Patent					Assay Description Recombinant Nav1.7 Cell Line: In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN...				US Patent US10202344 (2019) BindingDB Entry DOI: 10.7270/Q2X350KJ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM196483 (US10202344, Compound 152 | US9212139, 152) Show SMILES NC(=O)c1nn(-c2ccc(Oc3ccc(c(c3)C#N)C(F)(F)F)cc2)c2ccccc12 Show InChI InChI=1S/C22H13F3N4O2/c23-22(24,25)18-10-9-16(11-13(18)12-26)31-15-7-5-14(6-8-15)29-19-4-2-1-3-17(19)20(28-29)21(27)30/h1-11H,(H2,27,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	602	n/a	n/a	n/a	n/a	7.3	n/a
Purdue Pharma, L.P. US Patent					Assay Description Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...				US Patent US9212139 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W19
					More data for this Ligand-Target Pair