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SMILES: CN1C(=O)C(CCC1(C)C)c1ccc(cn1)C#Cc1cccc(F)c1

InChI Key: InChIKey=RZADELXKYYDCDV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196688   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 1 of Metabotropic glutamate receptor 5 (5a)


(Homo sapiens (Human))		BDBM196688
PNG
(US9212171, 13)
Show SMILES CN1C(=O)C(CCC1(C)C)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C21H21FN2O/c1-21(2)12-11-18(20(25)24(21)3)19-10-9-16(14-23-19)8-7-15-5-4-6-17(22)13-15/h4-6,9-10,13-14,18H,11-12H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 98n/an/an/a37



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...

US Patent US9212171 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TWH
More data for this
Ligand-Target Pair