BDBM198226 US9216999, 34::US9556187, Example 210

SMILES: N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1

InChI Key: InChIKey=QUQWPSPYENPYJL-UHFFFAOYSA-N

Data: 14 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 198226   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	n/a
Nissan Chemical Industries, Ltd. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9216999 (2015) BindingDB Entry DOI: 10.7270/Q28C9V2J
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	7.5	n/a
Nissan Chemical Industries, Ltd. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9216999 (2015) BindingDB Entry DOI: 10.7270/Q28C9V2J
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	7.5	n/a
Nissan Chemical Industries, Ltd. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9216999 (2015) BindingDB Entry DOI: 10.7270/Q28C9V2J
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.5	n/a
Nissan Chemical Industries, Ltd. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9216999 (2015) BindingDB Entry DOI: 10.7270/Q28C9V2J
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM198226 (US9216999, 34 | US9556187, Example 210) Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1 Show InChI InChI=1S/C20H19N7/c21-11-14-1-3-15(4-2-14)12-26-9-6-16(7-10-26)18-19-17-5-8-22-20(17)23-13-27(19)25-24-18/h1-5,8,13,16,22H,6-7,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	25
NISSAN CHEMICAL INDUSTRIES, LTD. US Patent					Assay Description JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...				US Patent US9556187 (2017) BindingDB Entry DOI: 10.7270/Q2BG2R1V
					More data for this Ligand-Target Pair