null

SMILES: COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C

InChI Key: InChIKey=VDRAMRAAPSBWGS-LJQANCHMSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 200328   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proprotein convertase subtilisin/kexin type 9 (Homo sapiens (Human))	BDBM200328 (US9227956, 13) Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C24H27N5O3/c1-16-6-4-13-26-22(16)29(19-7-5-12-25-14-19)23(30)18-10-8-17(9-11-18)20-15-27-28(2)21(20)24(31)32-3/h4,6,8-11,13,15,19,25H,5,7,12,14H2,1-3H3/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (Homo sapiens (Human))	BDBM200328 (US9227956, 13) Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C24H27N5O3/c1-16-6-4-13-26-22(16)29(19-7-5-12-25-14-19)23(30)18-10-8-17(9-11-18)20-15-27-28(2)21(20)24(31)32-3/h4,6,8-11,13,15,19,25H,5,7,12,14H2,1-3H3/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair