BDBM20387 3-isoquinolin-5-yl-1-{phenyl[4-(trifluoromethyl)phenyl]methyl}urea::isoquinoline antagonist, 5e

SMILES: FC(F)(F)c1ccc(cc1)C(NC(=O)Nc1cccc2cnccc12)c1ccccc1

InChI Key: InChIKey=GDMIQADOPFXIJS-UHFFFAOYSA-N

Data: 1 EC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20387   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20387 (3-isoquinolin-5-yl-1-{phenyl[4-(trifluoromethyl)ph...) Show SMILES FC(F)(F)c1ccc(cc1)C(NC(=O)Nc1cccc2cnccc12)c1ccccc1 Show InChI InChI=1S/C24H18F3N3O/c25-24(26,27)19-11-9-17(10-12-19)22(16-5-2-1-3-6-16)30-23(31)29-21-8-4-7-18-15-28-14-13-20(18)21/h1-15,22H,(H2,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	147	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...				Bioorg Med Chem Lett 17: 3894-9 (2007) Article DOI: 10.1016/j.bmcl.2007.04.105 BindingDB Entry DOI: 10.7270/Q2NV9GH2
					More data for this Ligand-Target Pair