BDBM204989 US9249085, I(aw)::US9624159, Compound I(aw)

SMILES: Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(cc(F)c1C)-c1cccc(F)c1

InChI Key: InChIKey=FRNXMPGECMYQSP-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 204989   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM204989 (US9249085, I(aw) | US9624159, Compound I(aw)) Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(cc(F)c1C)-c1cccc(F)c1 Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-22(30-13-23(28)29)16(3)24(14)27-12-19-9-18(11-21(26)15(19)2)17-5-4-6-20(25)10-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
FOVEA PHARMACEUTICALS US Patent					Assay Description Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...				US Patent US9249085 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02N8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM204989 (US9249085, I(aw) | US9624159, Compound I(aw)) Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(cc(F)c1C)-c1cccc(F)c1 Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-22(30-13-23(28)29)16(3)24(14)27-12-19-9-18(11-21(26)15(19)2)17-5-4-6-20(25)10-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>300	n/a	n/a	n/a	n/a	n/a	n/a
SANOFI US Patent					Assay Description Cell membrane homogenate from Human embryonic kidney HEK-293(T) cells expressing recombinant human prostanoid EP4 receptor was used to perform Prosta...				US Patent US9624159 (2017) BindingDB Entry DOI: 10.7270/Q2QZ2D2D
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM204989 (US9249085, I(aw) | US9624159, Compound I(aw)) Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(cc(F)c1C)-c1cccc(F)c1 Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-22(30-13-23(28)29)16(3)24(14)27-12-19-9-18(11-21(26)15(19)2)17-5-4-6-20(25)10-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>300	n/a	n/a	n/a	n/a	6.0	n/a
FOVEA PHARMACEUTICALS US Patent					Assay Description The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...				US Patent US9249085 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02N8
					More data for this Ligand-Target Pair