BDBM206098 US9255110, 11
SMILES: COc1cc2ncccc2cc1NC(=O)c1csc2cnc(NCCN)nc12
InChI Key: InChIKey=DURNYYKOVXELMP-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human)) | BDBM206098 (US9255110, 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
ROCHE PALO ALTO LLC; HOFFMANN-LA ROCHE INC. US Patent | Assay Description Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP... | US Patent US9255110 (2016) BindingDB Entry DOI: 10.7270/Q2XG9PZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM206098 (US9255110, 11) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | 7.2 | 25 |
ROCHE PALO ALTO LLC; HOFFMANN-LA ROCHE INC. US Patent | Assay Description SYK activity is measured by phosphorylation of a peptide substrate (Biotin-EPEGDYEEVLE) with [gamma-33P] ATP. The enzyme reaction was conducted at 20... | US Patent US9255110 (2016) BindingDB Entry DOI: 10.7270/Q2XG9PZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 receptor-associated kinase 1 (Homo sapiens (Human)) | BDBM206098 (US9255110, 11) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 712 | n/a | n/a | n/a | n/a | n/a | n/a |
ROCHE PALO ALTO LLC; HOFFMANN-LA ROCHE INC. US Patent | Assay Description Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP... | US Patent US9255110 (2016) BindingDB Entry DOI: 10.7270/Q2XG9PZ2 | |||||||||||
More data for this Ligand-Target Pair |