null
SMILES: CN1C(=O)C(=C(c2cn(C)c3cc(Cl)ccc23)C1(O)Cc1ccc(Cl)cc1)c1ccc(Cl)cc1
InChI Key: InChIKey=HJRYLJCJRYOUJE-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase Mdm2 [1-118,T47W] (Homo sapiens (Human)) | BDBM207980 (N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1-methyl-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 4.05E+4 | n/a | n/a | n/a | 7.4 | 25 |
Jagiellonian University | Assay Description MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W... | ACS Chem Biol 11: 3310-3318 (2016) Article DOI: 10.1021/acschembio.6b00596 BindingDB Entry DOI: 10.7270/Q2K35SH2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [1-118] (Homo sapiens (Human)) | BDBM207980 (N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1-methyl-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 3.65E+5 | n/a | n/a | n/a | 7.4 | 15 |
Jagiellonian University | Assay Description Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi... | ACS Chem Biol 11: 3310-3318 (2016) Article DOI: 10.1021/acschembio.6b00596 BindingDB Entry DOI: 10.7270/Q2K35SH2 | |||||||||||
More data for this Ligand-Target Pair |