BDBM209280 US9266883, 38

SMILES: CN(C)CCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N

InChI Key: InChIKey=XLGUWBQKZJAXCG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 209280   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 4 (FGFR4) (Homo sapiens (Human))	BDBM209280 (US9266883, 38) Show SMILES CN(C)CCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N Show InChI InChI=1S/C20H22N6O3/c1-25(2)8-9-29-17-10-18(22-12-15(17)11-21)24-20(28)26-7-3-4-14-5-6-16(13-27)23-19(14)26/h5-6,10,12-13H,3-4,7-9H2,1-2H3,(H,22,24,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.6	n/a	n/a	n/a	n/a	7.5	30
Novartis AG US Patent					Assay Description Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...				US Patent US9266883 (2016) BindingDB Entry DOI: 10.7270/Q2CC0ZGP
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM209280 (US9266883, 38) Show SMILES CN(C)CCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N Show InChI InChI=1S/C20H22N6O3/c1-25(2)8-9-29-17-10-18(22-12-15(17)11-21)24-20(28)26-7-3-4-14-5-6-16(13-27)23-19(14)26/h5-6,10,12-13H,3-4,7-9H2,1-2H3,(H,22,24,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	588	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of TEL-fused FGFR4 cytoplasmic/juxta membrane domain (unknown origin) expressed in mouse Ba/F3 cells assessed as reduction in FGFR4 autoph...				ACS Med Chem Lett 9: 215-220 (2018) Article DOI: 10.1021/acsmedchemlett.7b00485 BindingDB Entry DOI: 10.7270/Q27947C7
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM209280 (US9266883, 38) Show SMILES CN(C)CCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N Show InChI InChI=1S/C20H22N6O3/c1-25(2)8-9-29-17-10-18(22-12-15(17)11-21)24-20(28)26-7-3-4-14-5-6-16(13-27)23-19(14)26/h5-6,10,12-13H,3-4,7-9H2,1-2H3,(H,22,24,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKKEEIYFFFG-NH2 as substrate after 60 mins by microfluidic mobility shif...				ACS Med Chem Lett 9: 215-220 (2018) Article DOI: 10.1021/acsmedchemlett.7b00485 BindingDB Entry DOI: 10.7270/Q27947C7
					More data for this Ligand-Target Pair