BDBM209464 US10328074, Example III-5::US9266891, III-5
SMILES: COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccc(F)cc1
InChI Key: InChIKey=TUSWVDDMTVUGBQ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BRD4 BD1 (aa 42-168) (Homo sapiens (Human)) | BDBM209464 (US10328074, Example III-5 | US9266891, III-5) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR... | Bioorg Med Chem 17: 7324-36 (2009) BindingDB Entry DOI: 10.7270/Q20Z75M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BRD4-BD1 and Histone H4 (Homo sapiens (Human)) | BDBM209464 (US10328074, Example III-5 | US9266891, III-5) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme... | US Patent US9266891 (2016) BindingDB Entry DOI: 10.7270/Q23X85G7 | |||||||||||
More data for this Ligand-Target Pair |