BDBM214690 US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol
SMILES: Cc1cc(Nc2nc(nc3ccccc23)[C@H](O)c2ccc(F)cc2)n[nH]1
InChI Key: InChIKey=DCRWIATZWHLIPN-QGZVFWFLSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | 25 |
Ambit Biosciences Corporation US Patent | Assay Description For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 25 |
Ambit Biosciences Corporation US Patent | Assay Description For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | 25 |
Ambit Biosciences Corporation US Patent | Assay Description For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | 25 |
Ambit Biosciences Corporation US Patent | Assay Description For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Corporation US Patent | Assay Description .(R)- and (S)-(4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol was tested in a radioligand binding assay, according to th... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 28.5 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Corporation US Patent | Assay Description .(R)- and (S)-(4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol was tested in a radioligand binding assay, according to th... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Ambit Biosciences Corporation US Patent | Assay Description The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2B6 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Ambit Biosciences Corporation US Patent | Assay Description The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C8 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 2.69E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Ambit Biosciences Corporation US Patent | Assay Description The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Ambit Biosciences Corporation US Patent | Assay Description The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C19 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Ambit Biosciences Corporation US Patent | Assay Description The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Ambit Biosciences Corporation US Patent | Assay Description The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 1A (Homo sapiens (Human)) | BDBM214690 (US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-py...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
Ambit Biosciences Corporation US Patent | Assay Description The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met... | US Patent US9295672 (2016) BindingDB Entry DOI: 10.7270/Q2ZP44ZX | |||||||||||
More data for this Ligand-Target Pair |