BDBM217044 US9302989, 336
SMILES: O=C(Nc1ccc(cc1)N1CCN(CC1)C(=O)c1ccccc1)N1Cc2ccccc2C1
InChI Key: InChIKey=HCQKWBKNBHARJA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM217044 (US9302989, 336) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com. Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-... | Bioorg Med Chem Lett 27: 3317-3325 (2017) Article DOI: 10.1016/j.bmcl.2017.06.018 BindingDB Entry DOI: 10.7270/Q2D22123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM217044 (US9302989, 336) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 25.9 | n/a | n/a | n/a | n/a | 7.5 | n/a |
AbbVie Inc. US Patent | Assay Description Probe 1:The assay was carried out in 18 uL low volume plates (Owens Corning) in reaction buffer (50 mM HEPES (NaOH), pH 7.5, 100 mM NaCl, 10 mM MgCl2... | US Patent US9302989 (2016) BindingDB Entry DOI: 10.7270/Q2HH6HX1 | |||||||||||
More data for this Ligand-Target Pair |