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SMILES: Cn1c2c3C(NCCn3c(-c3ccccc3)c2c(=O)n(C)c1=O)c1nc(cs1)C(F)(F)F

InChI Key: InChIKey=VPEYIFRRWSZIAC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 221941   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Cricetulus griseus (Chinese hamster))	BDBM221941 (US9303035, 1.9 | US9303035, 2.4) Show SMILES Cn1c2c3C(NCCn3c(-c3ccccc3)c2c(=O)n(C)c1=O)c1nc(cs1)C(F)(F)F Show InChI InChI=1S/C21H18F3N5O2S/c1-27-16-13(19(30)28(2)20(27)31)15(11-6-4-3-5-7-11)29-9-8-25-14(17(16)29)18-26-12(10-32-18)21(22,23)24/h3-7,10,14,25H,8-9H2,1-2H3	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.98	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...				US Patent US9303035 (2016) BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Cricetulus griseus (Chinese hamster))	BDBM221941 (US9303035, 1.9 | US9303035, 2.4) Show SMILES Cn1c2c3C(NCCn3c(-c3ccccc3)c2c(=O)n(C)c1=O)c1nc(cs1)C(F)(F)F Show InChI InChI=1S/C21H18F3N5O2S/c1-27-16-13(19(30)28(2)20(27)31)15(11-6-4-3-5-7-11)29-9-8-25-14(17(16)29)18-26-12(10-32-18)21(22,23)24/h3-7,10,14,25H,8-9H2,1-2H3	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.31	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...				US Patent US9303035 (2016) BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
					More data for this Ligand-Target Pair