BDBM22254 2,4,5-tri-substituted imidazole, 21b::N-{2-[5-(4-methoxyphenyl)-2-(thiophen-2-yl)-1H-imidazol-4-yl]ethyl}-4-pentylpiperazine-1-sulfonamide

SMILES: CCCCCN1CCN(CC1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1

InChI Key: InChIKey=XOMUQLAAMXZNKY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22254   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 15-lipoxygenase (Oryctolagus cuniculus (rabbit))	BDBM22254 (2,4,5-tri-substituted imidazole, 21b | N-{2-[5-(4-...) Show SMILES CCCCCN1CCN(CC1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1 Show InChI InChI=1S/C25H35N5O3S2/c1-3-4-5-14-29-15-17-30(18-16-29)35(31,32)26-13-12-22-24(20-8-10-21(33-2)11-9-20)28-25(27-22)23-7-6-19-34-23/h6-11,19,26H,3-5,12-18H2,1-2H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...				Bioorg Med Chem Lett 17: 5115-20 (2007) Article DOI: 10.1016/j.bmcl.2007.07.011 BindingDB Entry DOI: 10.7270/Q2XW4H31
					More data for this Ligand-Target Pair