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SMILES: C1CC1c1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1

InChI Key: InChIKey=NMOAVWCJECIOPM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 225074   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM225074 (US9321756, 43) Show SMILES C1CC1c1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1 Show InChI InChI=1S/C20H17N5O/c1-2-11(1)16-7-8-21-18(23-16)15-10-22-17-6-5-13(9-14(15)17)20-25-24-19(26-20)12-3-4-12/h5-12,22H,1-4H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.32	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM225074 (US9321756, 43) Show SMILES C1CC1c1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1 Show InChI InChI=1S/C20H17N5O/c1-2-11(1)16-7-8-21-18(23-16)15-10-22-17-6-5-13(9-14(15)17)20-25-24-19(26-20)12-3-4-12/h5-12,22H,1-4H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.58	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair