BDBM228154 (S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazin-2- yl)pyrimidin-2-amine::US9556203, 25

SMILES: Nc1ncc(cn1)-c1nc2N3CCOC[C@@H]3Cc2c(n1)N1CCOCC1

InChI Key: InChIKey=WLHXVOYGBREFJO-LBPRGKRZSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 228154   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM228154 ((S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...) Show SMILES Nc1ncc(cn1)-c1nc2N3CCOC[C@@H]3Cc2c(n1)N1CCOCC1 |r| Show InChI InChI=1S/C17H21N7O2/c18-17-19-8-11(9-20-17)14-21-15(23-1-4-25-5-2-23)13-7-12-10-26-6-3-24(12)16(13)22-14/h8-9,12H,1-7,10H2,(H2,18,19,20)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8	n/a	76	n/a	n/a	n/a	n/a	7.5	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description N-terminally His-tagged PI3K alpha (Cat. No. PV4789; 0.49 mg/ml), Alexa Fluor® 647 labeled kinase Tracer 314 (Cat. No. PV6087), Biotin anti-His Tag a...				US Patent US9556191 (2017) BindingDB Entry DOI: 10.7270/Q22R3TPV
					More data for this Ligand-Target Pair