null
SMILES: CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1
InChI Key: InChIKey=ZUXABONWMNSFBN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 13.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vernalis Research Curated by PDSP Ki Database | Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) Article DOI: 10.1007/s00210-004-0951-4 BindingDB Entry DOI: 10.7270/Q2M32TBD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals Inc. | Assay Description R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80... | J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals Inc. | Assay Description R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80... | J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals Inc. | Assay Description R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80... | J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 0.550 | -11.7 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
ACADIA Pharmaceuticals Inc. | Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe... | J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30 | -11.3 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
ACADIA Pharmaceuticals Inc. | Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe... | J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 143 | -9.33 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College | Assay Description The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris¿HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5... | Chem Biol Drug Des 85: 326-35 (2015) Article DOI: 10.1111/cbdd.12394 BindingDB Entry DOI: 10.7270/Q2DN43SZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 4 | -11.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College | Assay Description The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris¿HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5... | Chem Biol Drug Des 85: 326-35 (2015) Article DOI: 10.1111/cbdd.12394 BindingDB Entry DOI: 10.7270/Q2DN43SZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 18 | -10.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College | Assay Description The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris¿HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5... | Chem Biol Drug Des 85: 326-35 (2015) Article DOI: 10.1111/cbdd.12394 BindingDB Entry DOI: 10.7270/Q2DN43SZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 18 | -10.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College | Assay Description All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room... | Chem Biol Drug Des 86: 697-703 (2015) Article DOI: 10.1111/cbdd.12539 BindingDB Entry DOI: 10.7270/Q2DR2T86 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 143 | -9.33 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College | Assay Description All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room... | Chem Biol Drug Des 86: 697-703 (2015) Article DOI: 10.1111/cbdd.12539 BindingDB Entry DOI: 10.7270/Q2DR2T86 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Biologie Structurale | Assay Description The ability of Compound 102 to bind dopamine D2 receptors was measured in a cell-based assay. Dopamine D2 receptor cells were seeded in a half a blac... | J Med Chem 51: 1115-25 (2008) BindingDB Entry DOI: 10.7270/Q2377C1M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM22869 (6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Biologie Structurale | Assay Description The ability of Compound 102 to bind the dopamine D2 receptor in a membrane preparation was examined. Medium was removed from dopamine D2 receptor cel... | J Med Chem 51: 1115-25 (2008) BindingDB Entry DOI: 10.7270/Q2377C1M | |||||||||||
More data for this Ligand-Target Pair |
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