BDBM234482 US10004738, 35::US9353084, 35

SMILES: Cc1nc(no1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@](C)(F)CC1(F)F

InChI Key: InChIKey=WMKOPKSKWBVFKU-HZPDHXFCSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 234482   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM234482 (US10004738, 35 | US9353084, 35) Show SMILES Cc1nc(no1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@](C)(F)CC1(F)F |r,t:20| Show InChI InChI=1S/C17H17F4N5O2/c1-8-23-12(26-28-8)13(27)24-9-4-5-11(18)10(6-9)16(3)17(20,21)7-15(2,19)14(22)25-16/h4-6H,7H2,1-3H3,(H2,22,25)(H,24,27)/t15-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...				J Med Chem 52: 6621-36 (2009) BindingDB Entry DOI: 10.7270/Q2B85BGS
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM234482 (US10004738, 35 | US9353084, 35) Show SMILES Cc1nc(no1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@](C)(F)CC1(F)F |r,t:20| Show InChI InChI=1S/C17H17F4N5O2/c1-8-23-12(26-28-8)13(27)24-9-4-5-11(18)10(6-9)16(3)17(20,21)7-15(2,19)14(22)25-16/h4-6H,7H2,1-3H3,(H2,22,25)(H,24,27)/t15-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	680	n/a	n/a	n/a	n/a	n/a	n/a	4.5	n/a
H. Lundbeck A/S US Patent					Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...				US Patent US9353084 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NDX
					More data for this Ligand-Target Pair