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SMILES: CN1CCN(CC1)c1cnc2c(NCCCn3cncn3)nc(nc2n1)-c1ccccc1

InChI Key: InChIKey=RNHZXCWUEBJJPH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 235722   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 9 (Homo sapiens (Human))	BDBM235722 (US10117875, Example 64 | US9359361, 64) Show SMILES CN1CCN(CC1)c1cnc2c(NCCCn3cncn3)nc(nc2n1)-c1ccccc1 Show InChI InChI=1S/C22H26N10/c1-30-10-12-31(13-11-30)18-14-25-19-21(24-8-5-9-32-16-23-15-26-32)28-20(29-22(19)27-18)17-6-3-2-4-7-17/h2-4,6-7,14-16H,5,8-13H2,1H3,(H,24,27,28,29)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
JANUS BIOTHERAPEUTICS, INC. US Patent					Assay Description HEK-Blue-hTLR9 cells were obtained from InvivoGen Inc. and used to determine test compound antagonism of human TLR9 (hTLR9) driven responses. HEK-Blu...				US Patent US10117875 (2018) BindingDB Entry DOI: 10.7270/Q2MK6FXT
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM235722 (US10117875, Example 64 | US9359361, 64) Show SMILES CN1CCN(CC1)c1cnc2c(NCCCn3cncn3)nc(nc2n1)-c1ccccc1 Show InChI InChI=1S/C22H26N10/c1-30-10-12-31(13-11-30)18-14-25-19-21(24-8-5-9-32-16-23-15-26-32)28-20(29-22(19)27-18)17-6-3-2-4-7-17/h2-4,6-7,14-16H,5,8-13H2,1H3,(H,24,27,28,29)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.95E+3	n/a	n/a	n/a	n/a	n/a	37
JANUS BIOTHERAPEUTICS, INC. US Patent					Assay Description Day 1: A cell suspension of HEK-Blue™-hTLR9 cells at ~450,000 cells per ml in test medium which contained 5% (v/v) heat inactivated FBS was pre...				US Patent US9359361 (2016) BindingDB Entry DOI: 10.7270/Q2GH9GT3
					More data for this Ligand-Target Pair