BDBM235961 US9365546, 284

SMILES: Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O

InChI Key: InChIKey=WJYGDQYYYZYICM-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 235961   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p38 MAPK/ MAPKAP kinases MK2 (Homo sapiens (Human))	BDBM235961 (US9365546, 284) Show SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O |(-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-1.33,5.39,;,4.62,;,3.08,;1.33,2.31,;2.67,3.08,;4,2.31,;2.67,4.62,;1.33,5.39,;1.33,6.93,;-4,2.31,;-5.33,3.08,;-4,.77,;-5.33,,;,-4.62,;,-6.16,;1.33,-6.93,;2.67,-6.16,;2.67,-4.62,;1.33,-3.85,;4,-3.85,;3.23,-2.52,;4.77,-2.52,;5.33,-4.62,)| Show InChI InChI=1S/C26H23ClF2N4O3/c1-14-12-31-20(19-7-8-30-25(32-19)26(3,4)35)11-21(14)33-15(2)9-22(23(27)24(33)34)36-13-16-5-6-17(28)10-18(16)29/h5-12,35H,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	7.5	25
CONFLUENCE LIFE SCIENCES INC. US Patent					Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...				US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP
					More data for this Ligand-Target Pair
p38 MAPK/ MAPKAP kinases MK2 (Homo sapiens (Human))	BDBM235961 (US9365546, 284) Show SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O |(-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-1.33,5.39,;,4.62,;,3.08,;1.33,2.31,;2.67,3.08,;4,2.31,;2.67,4.62,;1.33,5.39,;1.33,6.93,;-4,2.31,;-5.33,3.08,;-4,.77,;-5.33,,;,-4.62,;,-6.16,;1.33,-6.93,;2.67,-6.16,;2.67,-4.62,;1.33,-3.85,;4,-3.85,;3.23,-2.52,;4.77,-2.52,;5.33,-4.62,)| Show InChI InChI=1S/C26H23ClF2N4O3/c1-14-12-31-20(19-7-8-30-25(32-19)26(3,4)35)11-21(14)33-15(2)9-22(23(27)24(33)34)36-13-16-5-6-17(28)10-18(16)29/h5-12,35H,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	144	n/a	n/a	n/a	n/a	7.5	25
CONFLUENCE LIFE SCIENCES INC. US Patent					Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...				US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP
					More data for this Ligand-Target Pair
p38 MAPK/ MAPKAP kinases MK2 (Homo sapiens (Human))	BDBM235961 (US9365546, 284) Show SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O |(-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-1.33,5.39,;,4.62,;,3.08,;1.33,2.31,;2.67,3.08,;4,2.31,;2.67,4.62,;1.33,5.39,;1.33,6.93,;-4,2.31,;-5.33,3.08,;-4,.77,;-5.33,,;,-4.62,;,-6.16,;1.33,-6.93,;2.67,-6.16,;2.67,-4.62,;1.33,-3.85,;4,-3.85,;3.23,-2.52,;4.77,-2.52,;5.33,-4.62,)| Show InChI InChI=1S/C26H23ClF2N4O3/c1-14-12-31-20(19-7-8-30-25(32-19)26(3,4)35)11-21(14)33-15(2)9-22(23(27)24(33)34)36-13-16-5-6-17(28)10-18(16)29/h5-12,35H,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	138	n/a	n/a	n/a	n/a	7.5	25
CONFLUENCE LIFE SCIENCES INC. US Patent					Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...				US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP
					More data for this Ligand-Target Pair
p38 MAPK/ MAPKAP kinases MK2 (Homo sapiens (Human))	BDBM235961 (US9365546, 284) Show SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O |(-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-1.33,5.39,;,4.62,;,3.08,;1.33,2.31,;2.67,3.08,;4,2.31,;2.67,4.62,;1.33,5.39,;1.33,6.93,;-4,2.31,;-5.33,3.08,;-4,.77,;-5.33,,;,-4.62,;,-6.16,;1.33,-6.93,;2.67,-6.16,;2.67,-4.62,;1.33,-3.85,;4,-3.85,;3.23,-2.52,;4.77,-2.52,;5.33,-4.62,)| Show InChI InChI=1S/C26H23ClF2N4O3/c1-14-12-31-20(19-7-8-30-25(32-19)26(3,4)35)11-21(14)33-15(2)9-22(23(27)24(33)34)36-13-16-5-6-17(28)10-18(16)29/h5-12,35H,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	7.5	25
CONFLUENCE LIFE SCIENCES INC. US Patent					Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...				US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP
					More data for this Ligand-Target Pair