BDBM237809 US9394282, 5-88

SMILES: NC(=O)c1cn(nc1Nc1ccc(F)cc1)[C@@H]1CN(CC[C@H]1C#N)C(=O)OCC1(CC#N)CC1

InChI Key: InChIKey=BPONMCKOBOWVQW-HNAYVOBHSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 237809   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM237809 (US9394282, 5-88) Show SMILES NC(=O)c1cn(nc1Nc1ccc(F)cc1)[C@@H]1CN(CC[C@H]1C#N)C(=O)OCC1(CC#N)CC1 |r| Show InChI InChI=1S/C23H24FN7O3/c24-16-1-3-17(4-2-16)28-21-18(20(27)32)12-31(29-21)19-13-30(10-5-15(19)11-26)22(33)34-14-23(6-7-23)8-9-25/h1-4,12,15,19H,5-8,10,13-14H2,(H2,27,32)(H,28,29)/t15-,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9394282 (2016) BindingDB Entry DOI: 10.7270/Q2J10233
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM237809 (US9394282, 5-88) Show SMILES NC(=O)c1cn(nc1Nc1ccc(F)cc1)[C@@H]1CN(CC[C@H]1C#N)C(=O)OCC1(CC#N)CC1 |r| Show InChI InChI=1S/C23H24FN7O3/c24-16-1-3-17(4-2-16)28-21-18(20(27)32)12-31(29-21)19-13-30(10-5-15(19)11-26)22(33)34-14-23(6-7-23)8-9-25/h1-4,12,15,19H,5-8,10,13-14H2,(H2,27,32)(H,28,29)/t15-,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9394282 (2016) BindingDB Entry DOI: 10.7270/Q2J10233
					More data for this Ligand-Target Pair