BDBM238357 3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid (1e)
SMILES: CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(F)c1
InChI Key: InChIKey=LYRISHMYQQCWNO-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Saccharomyces cerevisiae (Baker's yeast)) | BDBM238357 (3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 460 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Centre de Recherche de Gif | Assay Description Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per... | J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase alpha subunit/subunit beta (Trypanosoma brucei brucei) | BDBM238357 (3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherche de Gif | Assay Description Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of... | J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM238357 (3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherche de Gif | Assay Description Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c... | J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ | |||||||||||
More data for this Ligand-Target Pair |