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SMILES: Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C

InChI Key: InChIKey=XKEPASMYHMOCPP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 238707   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238707 (US9394297, 371) Show SMILES Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H20FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-9,24H,1-4H3,(H,22,27)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.246	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238707 (US9394297, 371) Show SMILES Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H20FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-9,24H,1-4H3,(H,22,27)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0667	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238707 (US9394297, 371) Show SMILES Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H20FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-9,24H,1-4H3,(H,22,27)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1/pim-2/pim-3 (Homo sapiens (Human))	BDBM238707 (US9394297, 371) Show SMILES Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H20FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-9,24H,1-4H3,(H,22,27)(H,25,26)	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238707 (US9394297, 371) Show SMILES Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H20FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-9,24H,1-4H3,(H,22,27)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair