BDBM241637 US9409915, 20::US9718820, Compound 20

SMILES: COCCOc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F

InChI Key: InChIKey=UZNJWPQDAPQYSY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 241637   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM241637 (US9409915, 20 | US9718820, Compound 20) Show SMILES COCCOc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C24H25ClF3N5O2/c1-23(2,3)20-17(25)19(33(4)32-20)21-29-16-12-15(13-8-6-7-9-14(13)24(26,27)28)30-22(18(16)31-21)35-11-10-34-5/h6-9,12H,10-11H2,1-5H3,(H,29,31)	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	37
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...				US Patent US9409915 (2016) BindingDB Entry DOI: 10.7270/Q23J3BVJ
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM241637 (US9409915, 20 | US9718820, Compound 20) Show SMILES COCCOc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C24H25ClF3N5O2/c1-23(2,3)20-17(25)19(33(4)32-20)21-29-16-12-15(13-8-6-7-9-14(13)24(26,27)28)30-22(18(16)31-21)35-11-10-34-5/h6-9,12H,10-11H2,1-5H3,(H,29,31)	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...				US Patent US9718820 (2017) BindingDB Entry DOI: 10.7270/Q2RV0QQ5
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM241637 (US9409915, 20 | US9718820, Compound 20) Show SMILES COCCOc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C24H25ClF3N5O2/c1-23(2,3)20-17(25)19(33(4)32-20)21-29-16-12-15(13-8-6-7-9-14(13)24(26,27)28)30-22(18(16)31-21)35-11-10-34-5/h6-9,12H,10-11H2,1-5H3,(H,29,31)	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...				US Patent US9718820 (2017) BindingDB Entry DOI: 10.7270/Q2RV0QQ5
					More data for this Ligand-Target Pair