BDBM24174 3-N,3-N-diethyl-5,5-dimethyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido::thiophene containing compound, 37
SMILES: CCN(CC)C(=O)c1c(NC(=O)c2cccs2)sc2CCC(C)(C)Cc12
InChI Key: InChIKey=BCQPPORYBRTCLZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinesin-like protein 1 (Homo sapiens (Human)) | BDBM24174 (3-N,3-N-diethyl-5,5-dimethyl-2-N-(thiophene-2-)-4,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of KwaZulu-Natal (UKZN) Curated by ChEMBL | Assay Description Inhibition EG5 (unknown origin) | Bioorg Med Chem Lett 28: 2930-2938 (2018) Article DOI: 10.1016/j.bmcl.2018.07.007 BindingDB Entry DOI: 10.7270/Q2542R80 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Kinesin Spindle Protein Eg5 (Homo sapiens (Human)) | BDBM24174 (3-N,3-N-diethyl-5,5-dimethyl-2-N-(thiophene-2-)-4,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Kalypsys, Inc. | Assay Description KSP ATPase activity was determined by measuring production of ADP (ADPQuest Assay, DiscoverX). Raw fluorescence data were normalized to negative (DMS... | Bioorg Med Chem Lett 17: 3562-9 (2007) Article DOI: 10.1016/j.bmcl.2007.04.076 BindingDB Entry DOI: 10.7270/Q2QV3JT8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |