BDBM242883 US9427442, 11
SMILES: Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC2CC(F)(F)C2)C(N)=O)C(=O)Nc2c(F)cccc12
InChI Key: InChIKey=QHRXWPSDABHYNR-YIGJPRQDSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Notch 3-CBF1 (Homo sapiens (Human)) | BDBM242883![]() (US9427442, 11) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag... | US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Notch 1-CBF1 (Homo sapiens (Human)) | BDBM242883![]() (US9427442, 11) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag... | US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P | |||||||||||
More data for this Ligand-Target Pair |