null

SMILES: COC(=O)N[C@@H](C1CC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CC1

InChI Key: InChIKey=ORLUHJBAYLSCIA-YPGCJYANSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 243444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Genome polyprotein [810-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243444 (US9427428, 5 | US9433609, 5) Show SMILES COC(=O)N[C@@H](C1CC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CC1 |r| Show InChI InChI=1S/C42H44N8O6/c1-55-41(53)47-35(23-7-8-23)39(51)49-17-3-5-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-6-4-18-50(34)40(52)36(24-9-10-24)48-42(54)56-2/h11-16,19-24,33-36H,3-10,17-18H2,1-2H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.0390	n/a	n/a	n/a	n/a
Janssen Sciences Ireland UC US Patent					Assay Description The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...				US Patent US9427428 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VPJ
					More data for this Ligand-Target Pair
Genome polyprotein [810-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243444 (US9427428, 5 | US9433609, 5) Show SMILES COC(=O)N[C@@H](C1CC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CC1 |r| Show InChI InChI=1S/C42H44N8O6/c1-55-41(53)47-35(23-7-8-23)39(51)49-17-3-5-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-6-4-18-50(34)40(52)36(24-9-10-24)48-42(54)56-2/h11-16,19-24,33-36H,3-10,17-18H2,1-2H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.0580	n/a	n/a	n/a	n/a
Janssen Sciences Ireland UC US Patent					Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...				US Patent US9427428 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VPJ
					More data for this Ligand-Target Pair
Genome polyprotein [1973-2419,Y2165H] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243444 (US9427428, 5 | US9433609, 5) Show SMILES COC(=O)N[C@@H](C1CC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CC1 |r| Show InChI InChI=1S/C42H44N8O6/c1-55-41(53)47-35(23-7-8-23)39(51)49-17-3-5-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-6-4-18-50(34)40(52)36(24-9-10-24)48-42(54)56-2/h11-16,19-24,33-36H,3-10,17-18H2,1-2H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10.8	n/a	n/a	n/a	n/a
Janssen Sciences Ireland UC US Patent					Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...				US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD
					More data for this Ligand-Target Pair
Genome polyprotein [1657-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243444 (US9427428, 5 | US9433609, 5) Show SMILES COC(=O)N[C@@H](C1CC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CC1 |r| Show InChI InChI=1S/C42H44N8O6/c1-55-41(53)47-35(23-7-8-23)39(51)49-17-3-5-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-6-4-18-50(34)40(52)36(24-9-10-24)48-42(54)56-2/h11-16,19-24,33-36H,3-10,17-18H2,1-2H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.0390	n/a	n/a	n/a	n/a
Janssen Sciences Ireland UC US Patent					Assay Description The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...				US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD
					More data for this Ligand-Target Pair
Genome polyprotein [1657-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243444 (US9427428, 5 | US9433609, 5) Show SMILES COC(=O)N[C@@H](C1CC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CC1 |r| Show InChI InChI=1S/C42H44N8O6/c1-55-41(53)47-35(23-7-8-23)39(51)49-17-3-5-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-6-4-18-50(34)40(52)36(24-9-10-24)48-42(54)56-2/h11-16,19-24,33-36H,3-10,17-18H2,1-2H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.0580	n/a	n/a	n/a	n/a
Janssen Sciences Ireland UC US Patent					Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...				US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD
					More data for this Ligand-Target Pair
Genome polyprotein [1973-2419,Y2165H] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243444 (US9427428, 5 | US9433609, 5) Show SMILES COC(=O)N[C@@H](C1CC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CC1 |r| Show InChI InChI=1S/C42H44N8O6/c1-55-41(53)47-35(23-7-8-23)39(51)49-17-3-5-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-6-4-18-50(34)40(52)36(24-9-10-24)48-42(54)56-2/h11-16,19-24,33-36H,3-10,17-18H2,1-2H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10.8	n/a	n/a	n/a	n/a
Janssen Sciences Ireland UC US Patent					Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...				US Patent US9427428 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VPJ
					More data for this Ligand-Target Pair