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BDBM243452 US9427428, 16::US9433609, 16

SMILES: CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C

InChI Key: InChIKey=QSOJFGNBOSSTHL-BAXPHUFQSA-N

Data: 19 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 243452   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine protease NS3-NS5B


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a 0.00300n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (R30H)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31M)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (L31V)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93H)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)


(Hepatitis C virus genotype 1a (isolate H77) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (R30H)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
PDB

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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0170n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31M)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0930n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31V)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.411n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93H)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.343n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS3-NS5B


(Hepatitis C virus genotype 1a (isolate H) (HCV))
BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0980n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair