BDBM244618 US10226449, cpd 227::US9428502, 227

SMILES: Cc1nc(CCO)[nH]c1-c1cc(ccc1C)C(=O)N1CC(C1)c1ccc(cc1)C#N

InChI Key: InChIKey=SJYPKGGFZPSLLT-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 244618   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fatty acid synthase (Homo sapiens (Human))	BDBM244618 (US10226449, cpd 227 | US9428502, 227) Show SMILES Cc1nc(CCO)[nH]c1-c1cc(ccc1C)C(=O)N1CC(C1)c1ccc(cc1)C#N Show InChI InChI=1S/C24H24N4O2/c1-15-3-6-19(11-21(15)23-16(2)26-22(27-23)9-10-29)24(30)28-13-20(14-28)18-7-4-17(12-25)5-8-18/h3-8,11,20,29H,9-10,13-14H2,1-2H3,(H,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	4
3-V Biosciences, Inc. US Patent					Assay Description The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...				US Patent US9428502 (2016) BindingDB Entry DOI: 10.7270/Q20G3J23
					More data for this Ligand-Target Pair
NS3 serine protease (NS3) (Hepatitis C Virus (Virus))	BDBM244618 (US10226449, cpd 227 | US9428502, 227) Show SMILES Cc1nc(CCO)[nH]c1-c1cc(ccc1C)C(=O)N1CC(C1)c1ccc(cc1)C#N Show InChI InChI=1S/C24H24N4O2/c1-15-3-6-19(11-21(15)23-16(2)26-22(27-23)9-10-29)24(30)28-13-20(14-28)18-7-4-17(12-25)5-8-18/h3-8,11,20,29H,9-10,13-14H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Conforma Therapeutics Corporation					Assay Description The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...				J Med Chem 49: 5352-62 (2006) BindingDB Entry DOI: 10.7270/Q27M0B78
					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM244618 (US10226449, cpd 227 | US9428502, 227) Show SMILES Cc1nc(CCO)[nH]c1-c1cc(ccc1C)C(=O)N1CC(C1)c1ccc(cc1)C#N Show InChI InChI=1S/C24H24N4O2/c1-15-3-6-19(11-21(15)23-16(2)26-22(27-23)9-10-29)24(30)28-13-20(14-28)18-7-4-17(12-25)5-8-18/h3-8,11,20,29H,9-10,13-14H2,1-2H3,(H,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Conforma Therapeutics Corporation					Assay Description FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...				J Med Chem 49: 5352-62 (2006) BindingDB Entry DOI: 10.7270/Q27M0B78
					More data for this Ligand-Target Pair