BDBM244760 US10226449, cpd 370::US9428502, 370

SMILES: Cc1nc(c([nH]1)-c1cc(C(=O)N2CC(F)(C2)c2ccc(cc2)C#N)c(C)cc1C)C(F)(F)F

InChI Key: InChIKey=LPYNBQIJCZAZMH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 244760   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fatty acid synthase (Homo sapiens (Human))	BDBM244760 (US10226449, cpd 370 | US9428502, 370) Show SMILES Cc1nc(c([nH]1)-c1cc(C(=O)N2CC(F)(C2)c2ccc(cc2)C#N)c(C)cc1C)C(F)(F)F Show InChI InChI=1S/C24H20F4N4O/c1-13-8-14(2)19(9-18(13)20-21(24(26,27)28)31-15(3)30-20)22(33)32-11-23(25,12-32)17-6-4-16(10-29)5-7-17/h4-9H,11-12H2,1-3H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Conforma Therapeutics Corporation					Assay Description FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...				J Med Chem 49: 5352-62 (2006) BindingDB Entry DOI: 10.7270/Q27M0B78
					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM244760 (US10226449, cpd 370 | US9428502, 370) Show SMILES Cc1nc(c([nH]1)-c1cc(C(=O)N2CC(F)(C2)c2ccc(cc2)C#N)c(C)cc1C)C(F)(F)F Show InChI InChI=1S/C24H20F4N4O/c1-13-8-14(2)19(9-18(13)20-21(24(26,27)28)31-15(3)30-20)22(33)32-11-23(25,12-32)17-6-4-16(10-29)5-7-17/h4-9H,11-12H2,1-3H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	4
3-V Biosciences, Inc. US Patent					Assay Description The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...				US Patent US9428502 (2016) BindingDB Entry DOI: 10.7270/Q20G3J23
					More data for this Ligand-Target Pair