BDBM244930 US9422293, 157::US9738649, Example 157

SMILES: Fc1cc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)ccc1C(F)(F)F

InChI Key: InChIKey=XXVZXYJBYMCVSH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244930   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM244930 (US9422293, 157 | US9738649, Example 157) Show SMILES Fc1cc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)ccc1C(F)(F)F Show InChI InChI=1S/C26H25F7N6/c27-20-15-16(6-7-18(20)25(28,29)30)35-22-17-8-13-38(23-19(26(31,32)33)5-4-10-34-23)14-9-21(17)36-24(37-22)39-11-2-1-3-12-39/h4-7,10,15H,1-3,8-9,11-14H2,(H,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	37
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...				US Patent US9422293 (2016) BindingDB Entry DOI: 10.7270/Q2P55MD8
					More data for this Ligand-Target Pair
Vanilloid receptor (Rattus norvegicus (rat))	BDBM244930 (US9422293, 157 | US9738649, Example 157) Show SMILES Fc1cc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)ccc1C(F)(F)F Show InChI InChI=1S/C26H25F7N6/c27-20-15-16(6-7-18(20)25(28,29)30)35-22-17-8-13-38(23-19(26(31,32)33)5-4-10-34-23)14-9-21(17)36-24(37-22)39-11-2-1-3-12-39/h4-7,10,15H,1-3,8-9,11-14H2,(H,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA N.V. US Patent					Assay Description The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...				US Patent US9738649 (2017) BindingDB Entry DOI: 10.7270/Q2G73GVH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM244930 (US9422293, 157 | US9738649, Example 157) Show SMILES Fc1cc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)ccc1C(F)(F)F Show InChI InChI=1S/C26H25F7N6/c27-20-15-16(6-7-18(20)25(28,29)30)35-22-17-8-13-38(23-19(26(31,32)33)5-4-10-34-23)14-9-21(17)36-24(37-22)39-11-2-1-3-12-39/h4-7,10,15H,1-3,8-9,11-14H2,(H,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA N.V. US Patent					Assay Description HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...				US Patent US9738649 (2017) BindingDB Entry DOI: 10.7270/Q2G73GVH
					More data for this Ligand-Target Pair
Vanilloid receptor (Rattus norvegicus (rat))	BDBM244930 (US9422293, 157 | US9738649, Example 157) Show SMILES Fc1cc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)ccc1C(F)(F)F Show InChI InChI=1S/C26H25F7N6/c27-20-15-16(6-7-18(20)25(28,29)30)35-22-17-8-13-38(23-19(26(31,32)33)5-4-10-34-23)14-9-21(17)36-24(37-22)39-11-2-1-3-12-39/h4-7,10,15H,1-3,8-9,11-14H2,(H,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	37
Janssen Pharmaceutica NV US Patent					Assay Description The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...				US Patent US9422293 (2016) BindingDB Entry DOI: 10.7270/Q2P55MD8
					More data for this Ligand-Target Pair