BDBM245918 US9433609, 2::US9433609, 4
SMILES: CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C
InChI Key: InChIKey=IFNKSIUGOHTHBN-XIRTUYHBSA-N
Data: 18 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.540 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (Y93C) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0130 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.909 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B) (Hepatitis C virus genotype 1a (isolate H77) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0330 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (L28T) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 9.05 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (L28T) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0520 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (R30H) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2.69 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (R30H) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0560 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (L31F) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.81 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (L31F) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (L31M) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0520 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (L31V) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.38 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (L31V) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0480 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (Y93H) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2.88 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (Y93H) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0340 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS5A (Y93C) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.655 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B) (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM245918![]() (US9433609, 2 | US9433609, 4) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.0120 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist... | US Patent US9433609 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60FD | |||||||||||
More data for this Ligand-Target Pair |