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BDBM245921 US9433609, 11

SMILES: CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C

InChI Key: InChIKey=NUJYJEUAUQASEY-SJNLCZQDSA-N

Data: 10 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 245921   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.00600n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0120n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)


(Hepatitis C virus genotype 1a (isolate H77) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0480n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L28T)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.117n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93C)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<0.0130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31F)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0210n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31M)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0870n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (L31V)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.141n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (Y93H)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.167n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Serine protease NS5A (R30H)


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.0500n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...


US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair