null

SMILES: OCCC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2

InChI Key: InChIKey=JEJMTHXNLZACJL-GZLODIHRSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 250439   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM250439 (US9464044, 33) Show SMILES OCCC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2 |r,wU:11.12,TLB:3:5:11:31.7.8,12:11:31:5.6.32,10:5:31:11.9.8,THB:6:5:11:31.7.8,6:7:11:5.10.32,10:9:31:5.6.32,(9.91,.03,;8.82,-1.06,;7.33,-.66,;6.24,-1.75,;6.64,-3.23,;4.76,-1.35,;3.86,-3.27,;2.66,-2.6,;2.67,-.2,;3.43,.96,;4.76,.19,;2.09,.19,;.76,.96,;-.57,.19,;-.57,-1.35,;-1.91,.96,;-3.24,.19,;-4.57,.96,;-5.91,.19,;-6.68,-1.14,;-5.14,-1.14,;-7.24,.96,;-7.24,2.5,;-8.58,3.27,;-9.91,2.5,;-9.91,.96,;-8.58,.19,;-8.58,-1.35,;-1.14,2.3,;-2.68,2.3,;2.09,-1.35,;1.26,-3.25,;3.43,-2.12,)| Show InChI InChI=1S/C24H31FN2O5S/c25-18-3-1-2-4-19(18)33(31,32)26-14-23(6-7-23)22(30)27-21-16-9-15-10-17(21)13-24(11-15,12-16)20(29)5-8-28/h1-4,15-17,21,26,28H,5-14H2,(H,27,30)/t15?,16?,17?,21-,24?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	6.0	25
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION US Patent					Assay Description The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...				US Patent US9464044 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JH0
					More data for this Ligand-Target Pair