BDBM25288 BPH-629::[1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(13),2,4,6,9,11-hexaen-6-yl}phenyl)-1-phosphonoethyl]phosphonic acid::bisphosphonate, 8
SMILES: OC(Cc1cccc(c1)-c1cccc2c1oc1ccccc21)(P(O)(O)=O)P(O)(O)=O
InChI Key: InChIKey=BYVXAUZOTGITQZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Geranylgeranyl Diphosphate Synthase (GGPPS) (Homo sapiens (Human)) | BDBM25288 (BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem | Article PubMed | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry Curated by ChEMBL | Assay Description Binding affinity to human GGPPS | Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl diphosphate synthase (GGPPS) (Saccharomyces cerevisiae (Yeast)) | BDBM25288 (BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry Curated by ChEMBL | Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS | Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tuberculosinyl adenosine synthase (Rv3378c) (Mycobacterium tuberculosis H37Rv) | BDBM25288 (BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California San Diego | Assay Description For inhibition assay of Rv3378c, using tuberculosinyl diphosphate and adenosine as substrates, a mixture of 100 µM TPP, 100 µM adenosine,75 µg/mL Rv3... | Chem Biol Drug Des 85: 756-69 (2015) Article DOI: 10.1111/cbdd.12463 BindingDB Entry DOI: 10.7270/Q2ZG6QZN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Geranylgeranyl Diphosphate Synthase (GGPPS) (Homo sapiens (Human)) | BDBM25288 (BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry Curated by ChEMBL | Assay Description Inhibition of human GGPPS | Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cis-Decaprenyl diphosphate synthase (cis-DPPS) (Mycobacterium tuberculosis H37Rv) | BDBM25288 (BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of California San Diego | Assay Description We screened an in-house library of 53 compounds using trans-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by ... | Chem Biol Drug Des 85: 756-69 (2015) Article DOI: 10.1111/cbdd.12463 BindingDB Entry DOI: 10.7270/Q2ZG6QZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl Diphosphate Synthase (GGPPS) (Homo sapiens (Human)) | BDBM25288 (BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Taiwan University | Assay Description The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co... | J Med Chem 51: 5594-607 (2008) Article DOI: 10.1021/jm800325y BindingDB Entry DOI: 10.7270/Q2028PVT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl diphosphate synthase (GGPPS) (Saccharomyces cerevisiae (Yeast)) | BDBM25288 (BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry Curated by ChEMBL | Assay Description Inhibition of Saccharomyces cerevisiae GGPPS | Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |