BDBM25730 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea::US10383835, Compound 295::US8815951, 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea::Urea-based compound, 11::cid_7547
SMILES: Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1
InChI Key: InChIKey=ICUTUKXCWQYESQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Epoxide Hydrolase B (EHB) (Mycobacterium tuberculosis) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | 7.0 | 30 |
University of Alberta | Assay Description Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax... | J Mol Biol 381: 897-912 (2008) Article DOI: 10.1016/j.jmb.2008.06.030 BindingDB Entry DOI: 10.7270/Q2D50K94 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NLRP3 protein (Homo sapiens (Human)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2WD3Z10 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NLRP3 protein (Homo sapiens (Human)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 805 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2RN369N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epoxide hydrolase (MsEH) (Mus musculus (Mouse)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of California US Patent | Assay Description The invention also provide methods for assaying for epoxide hydrolase activity as diagnostic assay to identify individuals at increased risk for hype... | US Patent US8815951 (2014) BindingDB Entry DOI: 10.7270/Q2BP01G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epoxide hydrolase 1 (Homo sapiens (Human)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of California US Patent | Assay Description The invention also provide methods for assaying for epoxide hydrolase activity as diagnostic assay to identify individuals at increased risk for hype... | US Patent US8815951 (2014) BindingDB Entry DOI: 10.7270/Q2BP01G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Soluble Epoxide Hydrolase (Canis lupus familiaris (Dog) (Canis familiaris)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ... | US Patent US10383835 (2019) BindingDB Entry DOI: 10.7270/Q2XD141M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay | Bioorg Med Chem 19: 5585-95 (2011) Article DOI: 10.1016/j.bmc.2011.07.034 BindingDB Entry DOI: 10.7270/Q2V69JZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epoxide hydrolase (Equus caballus (Horse)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 267 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ... | US Patent US10383835 (2019) BindingDB Entry DOI: 10.7270/Q2XD141M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epoxide hydrolase (Ovis aries (Sheep)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ... | US Patent US10383835 (2019) BindingDB Entry DOI: 10.7270/Q2XD141M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Soluble Epoxide Hydrolase (Sus scrofa (Pig)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ... | US Patent US10383835 (2019) BindingDB Entry DOI: 10.7270/Q2XD141M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epoxide hydrolase 1 (Felis catus (Cat) (Felis silvestris catus)) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ... | US Patent US10383835 (2019) BindingDB Entry DOI: 10.7270/Q2XD141M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epoxide Hydrolase B (EHB) (Mycobacterium tuberculosis) | BDBM25730![]() (3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis recombinant EphB expressed in Escherichia coli BL21 using CMNPC as substrate after 30 mins by fluorescent as... | Bioorg Med Chem 19: 5585-95 (2011) Article DOI: 10.1016/j.bmc.2011.07.034 BindingDB Entry DOI: 10.7270/Q2V69JZ1 | |||||||||||
More data for this Ligand-Target Pair |